This paper examines the geopolitical confrontation between Iran and the U.S. as well as its consequence on a transformation of the existing world order. It comes to the conclusion that the U.S.-American sanctions policy does not only aim at the nuclear programme but also seeks to generally break the economic clout of a regional power acting independently from U.S. interests. The sanctions policy did neither solve the nuclear dossier nor did it curb Iran’s economic power. It is time for a fundamental change of course.